Relapses can have long-term effects on the central nervous system, including gait and vision challenges. Most people with NMO have proteins in their blood called anti- aquaporin 4 antibodies (AQP4), which are the cause of the disease. MOGAD causes inflammation on the brain, spinal cord and/or optic nerves and can result in the following symptoms: Lost or. In children with relapsing disease, studies suggest use of intravenous immunoglobulin (IVIG) and/or disease modifying therapies (DMTs). Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is the most recently defined inflammatory demyelinating disease of the central nervous system (CNS). The phenotypic spectrum of MOGAD has been reliably reproduced in international cohorts classic presentations associated with anti-MOG antibodies include acute. However, patients who experience more severe attacks and relapsing MOGAD are at risk for more severe deficits. Complete recovery from the onset attack is common in children, and in general the outcome is favorable. Furthermore, patients who fully recover vision after optic neuritis may experience transient returns of blurred vision during times of stress, exertion, or heat exposure. Most patients respond well to intravenous steroids, with some also requiring oral prednisone for one to four weeks. Patients can possibly note blurred vision, loss of color vision, difficulty with depth perception and glares or halos around lights at night. Compared to other autoimmune conditions such as AQP4 NMO, MOGAD patients tend to have a quicker recovery and cause less severe disability in most people. Disease modifying therapies (DMTs) including therapies for children with relapsing forms of MOGAD.At the Neuroscience Center, our goal is to stop symptoms and restore a child's normal growth and development with as few treatment-related side effects as possible. MOGAD Prognosis & Management Initially, the presence of anti-MOG was thought to be associated with fewer relapses and better outcomes than those with AQP-4 positive NMOSD, 5,8 but studies with longer follow-up times indicate higher relapse rates than previously reported.
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